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Optimization of parameters for coverage of low molecular weight proteins

✍ Scribed by Stephan A. Müller; Tibor Kohajda; Sven Findeiß; Peter F. Stadler; Stefan Washietl; Manolis Kellis; Martin von Bergen; Stefan Kalkhof

Publisher
Springer
Year
2010
Tongue
English
Weight
737 KB
Volume
398
Category
Article
ISSN
1618-2650

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A method is described to identify small molecule ligands that stabilize proteins. The procedure is based on the hypothesis that molecules of various sizes containing two to four charges should occasionally bind to unpaired charged sites on the surface of proteins and by crosslinking such residues st