The human retinal pigment epithelium (RPE) is a potential target tissue for directed transfer of candidate genes to treat age-related macular degeneration (AMD). The RPE is uniquely suited to gene therapy protocols that use liposome-mediated DNA transfer because of its high intrinsic phagocytic func
β¦ LIBER β¦
Optimization of non-viral gene transfer to human primary retinal pigment epithelial cells
β Scribed by Abul-Hassan, Khaled; Walmsley, Richard; Boulton, Mike
- Book ID
- 121262516
- Publisher
- Informa plc
- Year
- 2000
- Tongue
- English
- Weight
- 138 KB
- Volume
- 20
- Category
- Article
- ISSN
- 6854-1423
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## Abstract ## Background Retinal pigment epithelium (RPE) maintains the function of photoreceptors and eyesight and is an important target for gene delivery. Since in some diseases RPE cells proliferate uncontrollably, we investigated the role of cell cycle in nonβviral gene delivery into a RPE c