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Optimization of methods for the detection of BCR-ABL activity in Philadelphia-positive cells

✍ Scribed by Ashley Hamilton; Fatma Alhashimi; Svetlana Myssina; Heather G. Jorgensen; Tessa L. Holyoake

Book ID
113616563
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
262 KB
Volume
37
Category
Article
ISSN
0301-472X

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## Abstract BACH2 is a B‐cell‐specific transcription repressor and is also know as a tumor suppressor in B cell malignancy. Expression of BACH2 is induced in BCR‐ABL positive lymphoid cell lines including BV173 by imatinib, a molecular targeting agent for the treatment of chronic myeloid leukemia (