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Optimization of dendritic cell maturation and gene transfer by recombinant adenovirus

✍ Scribed by George Miller; Svenja Lahrs; Alaap B. Shah; Ronald P. DeMatteo


Book ID
105966635
Publisher
Springer-Verlag
Year
2003
Tongue
English
Weight
905 KB
Volume
52
Category
Article
ISSN
0340-7004

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## Background: Adenoviral gene transfer to adult skeletal muscle is hindered by several major limitations, including host immune responses and maturation-dependent loss of myofiber infectivity. ex vivo gene delivery is more efficient than direct viral injection in surmounting maturation-dependent a