Optimization of a small intestinal segment perfusion model for heat-stable enterotoxin A induced secretion in pigs

Lack of guanylyl cyclase C, the receptor

Lack of guanylyl cyclase C, the receptor for Escherichia coli heat-stable enterotoxin, results in reduced polyp formation and increased apoptosis in the multiple intestinal neoplasia (Min) mouse model

✍ Elizabeth A. Mann; Kris A. Steinbrecher; Carmen Stroup; David P. Witte; Mitchell 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 363 KB

## Abstract Guanylyl cyclase C (GC‐C), a transmembrane receptor for bacterial heat‐stable enterotoxin and the mammalian peptides guanylin and uroguanylin, mediates intestinal ion secretion and affects intestinal cell growth via cyclic GMP signaling. In intestinal tumors, GC‐C expression is maintain