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Optimization of a process for the production of (R)-2-hydroxy-4-phenylbutyric acid — an intermediate for inhibitors of angiotensin converting enzyme

✍ Scribed by Elke Schmidt; Oreste Ghisalba; Daniel Gygax; Gottfried Sedelmeier


Book ID
119131725
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
550 KB
Volume
24
Category
Article
ISSN
0168-1656

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“An efficient synthesis of ethyl (R)-2-h
✍ Gary A. Flynn; Douglas W. Beight 📂 Article 📅 1988 🏛 Elsevier Science 🌐 French ⚖ 171 KB

Optically pure Ethyl (R)-2-hydroxy-4-phenylbutyrate has been synthesized stereoselectively in 24% overall yield. The recent discovery of potent inhibitors of angiotensin-converting enzyme (ACE) which incorporate the ethyl N-substituted-(S)-2-amino-4-phenylbutyrate moiety as a comnon structural eleme