Optimization in Drug Discovery: In Vitro Methods

✍ Scribed by Gary W. Caldwell, Becki Hasting, John A. Masucci (auth.), Gary W. Caldwell, Zhengyin Yan (eds.)

Publisher: Humana Press
Year: 2014
Tongue: English
Leaves: 596
Series: Methods in Pharmacology and Toxicology
Edition: 2
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

Thoroughly revised and updated, Optimization in Drug Discovery: In Vitro Methods, Second Edition presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Written for the Methods in Pharmacology and Toxicology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Expert authors have developed and utilized these in vitro assays to achieve “drug-like” characteristics in addition to efficacy properties and good safety profiles of drug candidates.

Comprehensive and up-to-date, Optimization in Drug Discovery: In Vitro Methods, Second Edition aims to guide researchers down the difficult path to successful drug discovery and development.

✦ Table of Contents

Front Matter....Pages i-xvii
Back Matter....Pages 1-20
....Pages 21-37

✦ Subjects

Pharmacology/Toxicology

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