Optimization by experimental design of the adsorptive stripping voltammetric parameters in the determination of cinoxacin

✍ Scribed by Paola Gratteri; Sandra Furlanetto; Sergio Pinzauti; Riccardo Leardi; Piero Corti

• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: English
• Weight: 526 KB
• Volume: 7
• Category: Article
• ISSN: 1040-0397
• DOI: 10.1002/elan.1140071212

✦ Synopsis

The quinolone antibacterial agent cinoxacin was studied by adsorptive stripping voltammetry making use of its controlled interfacial accumulation on a static mercury drop electrode. Measurements were obtained in differential pulse mode and optimized by experimental design. The chemometric approach allowed the identification of a strong interaction between pH and pulse amplitude. The dynamic linear range of calibration was extended from 0.4 to 9 x lo-* M. Analyses of cinoxacin capsules and spiked human urine sample were carried out without the need of previous extraction or filtration. A cleanup procedure was required to separate cinoxacin from the human plasma matrix prior to adsorptive stripping analysis.