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Optimization and Validation of a Quantitative Capillary Electrophoresis Sodium Dodecyl Sulfate Method for Quality Control and Stability Monitoring of Monoclonal Antibodies

โœ Scribed by Salas-Solano, Oscar; Tomlinson, Brandon; Du, Sarah; Parker, Monica; Strahan, Alex; Ma, Stacey


Book ID
120653799
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
224 KB
Volume
78
Category
Article
ISSN
0003-2700

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A chromogenic substrate autography is described which allows characterization and quantification of serine proteases in crude systems after sodium dodecyl sulfate-polyacrylamide gel electrophoresis or isoelectric focusing. Separation of samples containing proteases by either method is followed by an