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Optimising technetium 99m diethylene triamine penta-acetate lung clearance in patients with the acquired immunodeficiency syndrome

✍ Scribed by Hans Wall; I. Provan C. Murray; Philip D. Jones; Douglas W. J. Mackey; Brenda M. Walker; Phillip Monaghan

Publisher: Springer
Year: 1991
Tongue: English
Weight: 666 KB
Volume: 18
Category: Article
ISSN: 0340-6997
DOI: 10.1007/bf00186646

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✦ Synopsis

Pneumocystis carinii pneumonia (PCP) has become a major cause of morbidity and mortality due to infectious diseases, largely as a result of the acquired immunodeficiency syndrome (AIDS) epidemic. Since the mortality from recurrent infection is between 40% and 60%, early diagnosis and therapy are the keys to survival. The role of technetium 99m diethylene triamine pentaacetate (DTPA) aerosol pulmonary clearance was studied in 81 patients with AIDS. The mathematical technique of curve stripping was found to be the optimal method of analysis and to provide an overall sensitivity of 94% for the detection of interstitial pneumonitis. The procedure was superior to standard pathology parameters and radiography and more convenient than gallium 67 scintigraphy.

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Different kinetics of lung clearance of technetium-99m labelled diethylene triamine penta-acetic acid in patients with sarcoidosis and smokers

✍ Ingela Brådvik; Per Wollmer; Eva Evander; Hildur Lárusdóttir; Berith Blom-Bülow; 📂 Article 📅 1994 🏛 Springer 🌐 English ⚖ 717 KB

The rate of clearance from the lungs of inhaled technetium-99m labelled diethylene triamine penta-acetic acid (99mTc-DTPA) is often increased in interstitial lung disease as well as in smoking. In smokers a bi-exponential clearance course of 99mTc-DTPA when measured over 3 h has previously been show