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Optimal use of regression models in genome-wide association studies

✍ Scribed by J. E. Powell; A. Kranis; J. Floyd; J. C. M. Dekkers; S. Knott; C. S. Haley


Book ID
114706509
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
402 KB
Volume
43
Category
Article
ISSN
0268-9146

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Meta-analysis of genome-wide association studies involves testing single nucleotide polymorphisms (SNPs) using summary statistics that are weighted sums of site-specific score or Wald statistics. This approach avoids having to pool individual-level data. We describe the weights that maximize the pow