Optimal Scheduling of Radiotherapy and Angiogenic Inhibitors

✍ Scribed by Ayla Ergun; Kevin Camphausen; Lawrence M. Wein

• Book ID: 104271834
• Publisher: Springer
• Year: 2003
• Tongue: English
• Weight: 224 KB
• Volume: 65
• Category: Article
• ISSN: 1522-9602
• DOI: 10.1016/s0092-8240(03)00006-5

✦ Synopsis

We incorporate a previously validated mathematical model of a vascularized tumor into an optimal control problem to determine the temporal scheduling of radiotherapy and angiogenic inhibitors that maximizes the control of a primary tumor. Our results reveal that optimal antiangiogenic monotherapy gives a large initial injection to attain a 20:1 ratio of tumor cell volume to supporting vasculature volume. It thereafter maintains this 20:1 ratio via a continuous dose rate that is intensified over time. The optimal radiation monotherapy schedule is characterized by a modest dose intensification over time. The best performance is achieved by our optimal combination regimen, where the antiangiogenic treatment again maintains a constant tumor-to-vasculature ratio, but is administered in a dose-intensified manner only during the latter portion of the radiation fractionation schedule.