Optimal Pulmonary Arterial Blood Pressure

✍ Scribed by M.A. Khanin; I.B. Bukharov

• Publisher: Elsevier Science
• Year: 1993
• Tongue: English
• Weight: 258 KB
• Volume: 162
• Category: Article
• ISSN: 0022-5193
• DOI: 10.1006/jtbi.1993.1098

✦ Synopsis

M. A. Khanin and I. B. Bukharov
Department of Microelectronics, K. E. Tsiolkovsky Institute of Aviation Technology, Moscow 103767, Russia

(Received on 5 December 1991, Accepted in revised form on 7 October 1992)

Based on the principle of minimum power, a mathematical model of the functional state of the pulmonary circulatory and respiratory systems is presented. The optimization model minimizes the power expended by the right heart and respiratory muscles. The pulmonary diffusing capacity control mechanism is considered. Mean pulmonary arterial blood pressure and ventilation are determined depending on oxygen transport parameters for man under normal and chronic pathological conditions. Theoretical results are compared with clinical data.