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Optimal dose de-escalation trial designs for novel contraceptives in women

โœ Scribed by Christoph Gerlinger; Harald Siedentop; Oke Gerke; Ilka Schellschmidt; Jan Endrikat


Book ID
113557692
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
220 KB
Volume
56
Category
Article
ISSN
0167-9473

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โœ John J. Hanfelt ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 133 KB ๐Ÿ‘ 2 views

Simon's optimal two-stage design is widely used to conduct single-dose phase II clinical trials. We extend this basic methodology to the situation where the researcher desires to test an experimental drug for activity at a low dose level, but is willing to increase the dose part-way through the tria