Optimal multi-stage designs for a phase
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John J. Hanfelt
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Article
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1999
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John Wiley and Sons
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English
โ 133 KB
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Simon's optimal two-stage design is widely used to conduct single-dose phase II clinical trials. We extend this basic methodology to the situation where the researcher desires to test an experimental drug for activity at a low dose level, but is willing to increase the dose part-way through the tria