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Optimal design and validation of antiviral siRNA for targeting HIV-1

✍ Scribed by Yuki Naito; Kyoko Nohtomi; Toshinari Onogi; Rie Uenishi; Kumiko Ui-Tei; Kaoru Saigo; Yutaka Takebe

Book ID
119907799
Publisher
BioMed Central
Year
2007
Tongue
English
Weight
740 KB
Volume
4
Category
Article
ISSN
1742-4690

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✍ Alexander L. Perryman; Jung-Hsin Lin; J. Andrew McCammon πŸ“‚ Article πŸ“… 2006 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 804 KB

## Abstract To test the anticorrelated relationship that was recently displayed in conventional molecular dynamics (MD) simulations, several different restrained MD simulations on a wild type and on the V82F/I84V drug‐resistant mutant of HIV‐1 protease were performed. This anticorrelated relationsh