✦ LIBER ✦

Optimal control of molecular resolution in supercritical-fluid chromatography with density programming

✍ Scribed by F. Van Puyvelde; P. Van Rompay; E.H. Chimowitz

Publisher: Elsevier Science
Year: 1992
Tongue: English
Weight: 843 KB
Volume: 5
Category: Article
ISSN: 0896-8446
DOI: 10.1016/0896-8446(92)90012-9

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✦ Synopsis

A technique which allows the a priori determination of optimal density programs for supercriticalfluid chromatography (SFC) is proposed. This new approach is meant to supersede heuristic methods for optimizing molecular resolution in SFC. The analysis is based upon optimal control theory applied to the treatment of molecular resolution in fixed beds with supercritical mobile phases. The optimal dynamic trajectories for the process operating conditions are found by solving the optimal control problem as posed here.

A comparison with published data for a seven-component separation illustrates the concepts and shows that the method proposed has the potential for establishing optimal separation strategies in SFC.

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