Optimal control of medical treatment: Adaptive control of blood glucose level in diabetic coma

✍ Scribed by Michitoshi Inoue; Fumihiko Kajiya; Hiroshi Inada; Akira Kitabatake; Masatsugu Hori; Sugao Fukui; Hiroshi Abe; Seiichi Takasugi; Toshiyuki Furukawa

• Publisher: Elsevier Science
• Year: 1976
• Tongue: English
• Weight: 642 KB
• Volume: 9
• Category: Article
• ISSN: 0010-4809
• DOI: 10.1016/0010-4809(76)90002-1

✦ Synopsis

The primary purpose of clinical decision-making is to determine the most adequate treatment for individual pathological conditions, and the process of diagnosis and treatment constitutes a feedback loop. The present study was undertaken to apply "optimal control theory" to this process of clinical decision-making. The basic requirements for the application of optimal control theory in the clinical setting is presented and a clinical application, "adaptive control program," is proposed for the control of blood glucose level in diabetic coma using a simulation model of blood glucose kinetics.