✦ LIBER ✦

Optimal control of bilinear systems: Time-varying effects of cancer drugs

✍ Scribed by Yeal Biran; Bayliss McInnis

Publisher: Elsevier Science
Year: 1979
Tongue: English
Weight: 385 KB
Volume: 15
Category: Article
ISSN: 0005-1098
DOI: 10.1016/0005-1098(79)90048-7

No coin nor oath required. For personal study only.

✦ Synopsis

A bilinear model is introduced to study the effects of anti-tumor drugs on the kinetics of the cell cycle. Optimal control theory is applied in the estimation of these timevarying effects based on a least squares fit of laboratory data. This methodology enables the authors to quantify the effects of a drug on each phase of the cell cycle. *

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