Optimal control of bacterial growth

✍ Scribed by G. D'ans; D. Gottlieb; P. Kokotovic

• Publisher: Elsevier Science
• Year: 1972
• Tongue: English
• Weight: 676 KB
• Volume: 8
• Category: Article
• ISSN: 0005-1098
• DOI: 10.1016/0005-1098(72)90083-0

✦ Synopsis

Theory and experiments with the nutrient flow control maximizing the amount of microorganisms, produced in transient and steady states of a chemostat process, stimulate applications of optimal control in microbiology.

Smmnary--A stabilizing feedback control is designed for Haldane-Monod model of microbial growth. The controlled process is optimal in the sense that it approaches the maximum production steady-state from any initial state, while the amount of microorganisms produced in transients is also maximized. Data from a series of experiments are given and used to adjust the model parameters. Satisfactory agreement between experimental and model transients is obtained.