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Optimal conditions for blastogenic response of peripheral blood lymphocytes to T and B cell mitogens in cynomolgus monkeys

โœ Scribed by Wafa Al-Kurdi-Norimine; Fumiko Ochikubo; Yasushi Ami; Kazuya Yamanouchi; Chieko Kai


Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
535 KB
Volume
33
Category
Article
ISSN
0275-2565

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We tested the ability of a series of known genotoxic agents to cause mutations at the hprt locus in peripheral blood T-lymphocytes of cynomolgus monkeys as measured by the ability to form clones in the presence of 6-thioguanine. Ethylmethane sulfonate (EMS, 300 mg/kg IP), chloroethylmethane sulfonat