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Optically active 1-(benzofuran-2-yl)ethanols and ethane-1,2-diols by enantiotopic selective bioreductions

✍ Scribed by Csaba Paizs; Monica Toşa; Cornelia Majdik; Paula Moldovan; Lajos Novák; Pál Kolonits; Adriana Marcovici; Florin-Dan Irimie; László Poppe


Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
171 KB
Volume
14
Category
Article
ISSN
0957-4166

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Kinetic resolution of 1-(benzofuran-2-yl
✍ Csaba Paizs; Monica Toşa; Viktória Bódai; György Szakács; Ildikó Kmecz; Béla Sim 📂 Article 📅 2003 🏛 Elsevier Science 🌐 English ⚖ 143 KB

Kinetic resolution of racemic 1-(benzofuran-2-yl)ethanols rac-1a-d was performed by lipase-catalyzed enantiomer selective acylation (E100) yielding (1R)-1-acetoxy-1-(benzofuran-2-yl)ethanes (R)-2a-d and (1S)-1-(benzofuran-2-yl)ethanols (S)-1a-d in highly enantiopure form. The degree of enantiomer se