Optical spectroscopic studies of the antitumor drug 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione(mitoxantrone)
โ Scribed by Lee, B. S.; Dutta, Prabir K.
- Book ID
- 120165098
- Publisher
- American Chemical Society
- Year
- 1989
- Tongue
- English
- Weight
- 1000 KB
- Volume
- 93
- Category
- Article
- ISSN
- 0022-3654
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D HA Q, a new antitumor agent, has been selected for clinical trial on the basis of its activity against a number of transplantable rodent tumors. In anticipation of the clinical trial of this agent, the pharmacology of DHAQ was studied in beagles by high-pressure liquid chromatographic and radioche
An oxygen analog of the antineoplastic anthraquinone, 1,4-dihydroxy-5,8-bis[ [2-(2-hydroxyethyl)amino]ethyl)amino -9,lO -anthracenedione, was synthesized. This compound, 1,4-dihydroxy-5,8bis[ [2-(2-hydroxyethoxy)ethyI]amino] -9,10-anthracenedione, was found to be inactive against P-388 lymphocytic l