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Optical skin biopsies by clinical CARS and multiphoton fluorescence/SHG tomography

✍ Scribed by K. König; H.G. Breunig; R. Bückle; M. Kellner-Höfer; M. Weinigel; E. Büttner; W. Sterry; J. Lademann

Book ID
102451767
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
202 KB
Volume
8
Category
Article
ISSN
1612-2011

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✦ Synopsis

The ultimate challenge for early diagnostics is labelfree high-resolution intratissue imaging without taking physical biopsies. A novel hybrid femtosecond laser tomograph provides in vivo optical biopsies of human skin based on non-linear excitation of autofluorescence and the detection of lipids and water by CARS. Applications include skin cancer detection, biosafety tests of intradermal nanoparticles, and the testing of anti-aging products.

μm

Overlay (CARS/autofluorescence) of the outermost skin layer (stratum corneum) of a healthy male volunteer

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