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Optical analysis of computed tomography images of the liver predicts fibrosis stage and distribution in chronic hepatitis C

✍ Scribed by Manuel Romero-Gómez; Emilio Gómez-González; Ana Madrazo; Marina Vera-Valencia; Luis Rodrigo; Ramón Pérez-Alvarez; Rosa Pérez-López; Victor M. Castellano-Megias; Manuel Nevado-Santos; Juan C. Alcón; Ricard Solá; José M. Pérez-Moreno; José M. Navarro; Raúl J. Andrade; Javier Salmerón; Manuel Fernández-López; Rafael Aznar; Moisés Diago

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
250 KB
Volume
47
Category
Article
ISSN
0270-9139

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✦ Synopsis

This study was undertaken to evaluate an image processing method for assessing liver fibrosis in conventional computed tomography (CT) scans in patients with chronic hepatitis C. Two cohorts (designated "estimation," n = 34; and "validation," n = 107) of chronic hepatitis C patients were assessed using digitized conventional helical CT. Weighted CT mean fibrosis (Fibro-CT) was calculated as a nonlinear weighted mean F-score for each sample. Fibrosis was defined according to Scheuer on the F0 to F4 scale by 2 pathologists blinded regarding the Fibro-CT data. Fibrosis according to Fibro-CT correlated with histology-determined fibrosis (r = 0.69; P < 0.001) and with increasing F-stage: F0 = 0.23 +/- 0.39; F1 = 0.90 +/- 0.99; F2 = 1.41 +/- 0.94; F3 = 2.79 +/- 0.55; F4 = 3.15 +/- 0.35 [analysis of variance: P < 0.0001). The receiver operating characteristics curve to diagnose significant fibrosis (>/=F2) was 0.83; 95% confidence interval (95%CI), 0.75 to 0.91; and, to diagnose advanced fibrosis (>/=F3), was 0.86, 95%CI: 0.80 to 0.93. The correlation between Fibro-CT and fibrosis was higher in patients with homogeneous distribution of fibrosis than in patients with heterogeneous distribution (r = 0.77 versus r = 0.43; P < 0.05).

Conclusion:

Optical digital analysis of ct images of the liver is effective in determining the stage and distribution of liver fibrosis in chronic hepatitis c. in patients with homogeneous fibrosis distribution, the correlation between fibro-ct and histology was better than in patients with heterogeneous distribution. fibro-ct is a simple to use, readily available, and useful method for the diagnosis of fibrosis in patients with chronic hepatitis c.

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