𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Opsonins in the hepatic clearance of pneumococci

✍ Scribed by B. A. Runyon

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
264 KB
Volume
7
Category
Article
ISSN
0270-9139

No coin nor oath required. For personal study only.

✦ Synopsis

An in situ isolated, perfused rat liver system was used to evaluate various opsonins for hepatic trapping and killing of encapsulated, virulent, type 3 pneumococci. Pneumococci were rapidly trapped in the liver in the presence of all potential opsonins including Hanks balanced salt solution with added colloid. However, with some of the potential opsonins the organisms remained viable and could be recovered from the liver. With others there was killing of pneumococci. The combination of rat antibody and complement was effective as an opsonin and produced about the same degree of killing as the same human components. When tested separately killing was not promoted by rat com-

πŸ“œ SIMILAR VOLUMES

Predicting the hepatic clearance of xeno
Predicting the hepatic clearance of xenobiotics in humans from in vitro data
✍ Betty-Ann Hoener πŸ“‚ Article πŸ“… 1994 πŸ› John Wiley and Sons 🌐 English βš– 449 KB

Values for V,, and K, determined during the in vitro metabolism of a xenobiotic to a known metabolite by a specific human isozyme of cytochrome P450 (P450) were used to predict the hepatic clearance (CLH) of the xenobiotic to that metabolite. The calculated CLH values were then compared to literatur