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Opposite roles of protein kinase C isoforms in proliferation, differentiation, apoptosis, and tumorigenicity of human HaCaT keratinocytes

✍ Scribed by H. Papp; G. Czifra; E. Bodó; J. Lázár; I. Kovács; M. Aleksza; I. Juhász; P. Ács; S. Sipka; L. Kovács; P.M. Blumberg; T. Bíró

Publisher: Springer
Year: 2004
Tongue: English
Weight: 446 KB
Volume: 61
Category: Article
ISSN: 1420-682X
DOI: 10.1007/s00018-004-4014-2

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Epidermal keratinocyte differentiation is a tightly regulated, stepwise process that requires protein kinase C (PKC) activation. Studies using cultured mouse keratinocytes induced to differentiate with Ca 2+ have indirectly implicated the α isoform of PKC in upregulation of "late" (granular cell) ep