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Opposite regulation of vitamin D receptor by ATRA in AML cells susceptible and resistant to vitamin D-induced differentiation

✍ Scribed by Elżbieta Gocek; Aleksandra Marchwicka; Hanna Baurska; Agnieszka Chrobak; Ewa Marcinkowska

Book ID
118480702
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
873 KB
Volume
132
Category
Article
ISSN
0960-0760

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## Abstract Induction of terminal differentiation is a conceptually attractive approach for the therapy of neoplastic diseases. Although vitamin D derivatives (deltanoids) can induce differentiation of AML cells __in vitro__, so far deltanoids have not been successfully brought to the clinic, due t