Opposite modulation of regulators of G protein signalling-2 (RGS2) and RGS4 expression by dopamine receptors in the rat striatum
โ Scribed by Muriel Geurts; Emmanuel Hermans; Jean-Marie Maloteaux
- Book ID
- 117473247
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 243 KB
- Volume
- 333
- Category
- Article
- ISSN
- 0304-3940
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A clone of the regulator of G-protein signalling, RGS9, was isolated from a rat striatum-minus-cerebellumminus-hippocampus subtracted library generated by directional tag polymerase chain reaction subtraction. The full-length cDNA clone encodes a 444 amino acid protein containing an 118 amino acid R
## Abstract Regulator of Gโprotein signalingโ2 (RGSโ2) belongs to a novel family of GTPaseโactivating proteins that rapidly turnโoff Gโprotein coupled receptor signaling. RGS proteins contain a characteristic RGS domain by which they interact with the ฮฑโsubunit of Gโproteins and drive them into the