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Opposite effects of the Hsp90 inhibitor Geldanamycin: induction of apoptosis in PC12, and differentiation in N2A cells

✍ Scribed by M.Dolores López-Maderuelo; Margarita Fernández-Renart; Carmen Moratilla; Jaime Renart

Book ID
117102713
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
296 KB
Volume
490
Category
Article
ISSN
0014-5793

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Both geldanamycin (GA) and radicicol (RA) are HSP90 binding agents that possess antitumour activities. Although the in vitro data indicated that the inhibitory constant of RA is much bigger than that of GA, the in vivo data on drug efficacy might reveal different results. We have recently shown that