Opposite effects of [Leu13,Pro34]NPY and NPY13-36 on hypnotic response to α2-adrenoceptor agonist dexmedetomidine microinjected into rat locus coeruleus
✍ Scribed by Ants Kask; Jaanus Harro; Lembit Rägo
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 577 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0893-6609
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✦ Synopsis
Neuropeptide Y is colocalised with noradrenaline in the locus coeruleus (LC). This study evaluated the effects of neuropeptide Y (NPY) Y 1 and Y2 receptor agonists on the hypnotic response to a2-agonist dexmedetomidine following the unilateral microinjection of these drugs into the vicinity of the locus coeruleus (LC). Dexmedetomidine alone (1 ug) induced a loss of righting reflex and sleep in all animals. [Leu31 Pro34]NPY (10 pmol) lenghtened, whereas NPY 13-36 (100 sleep. The duration of sleep was shortened in rats pretreated with pmol) shortened the time of latency to [Leu 3 1 ,Pro34]NPY. These data demonstrate that the hypnotic effect to dexmedetomidine in the LC can be modulated differentially by Y 1 and Y2 receptorselective agonists and provide additional evidence for NPYla2-adrenoceptor interaction in this brain area.