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Opposite effects of glutamate antagonists and antiparkinsonian drugs on the activities of DOPA decarboxylase and 5-HTP decarboxylase in the rat brain

✍ Scribed by Andrew Fisher; Michael S Starr


Book ID
113995053
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
169 KB
Volume
868
Category
Article
ISSN
0006-8993

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The present study examined the effects of the antiparkinsonian drug budipine on dopamine synthesis and release from L-DOPA in the substantia nigra of reserpine-treated rats. Budipine (at 100 microM, but not 10 microM) applied by reverse dialysis to the nigra caused a small and significant rise in do