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Opportunities and strategies for introducing pharmacogenetics into early drug development

✍ Scribed by John C. Chamberlain; Pieter H. Joubert


Book ID
114383523
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
46 KB
Volume
6
Category
Article
ISSN
1359-6446

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QT prolongation through hERG K+ channel
✍ Maurizio Recanatini; Elisabetta Poluzzi; Matteo Masetti; Andrea Cavalli; Fabrizi πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 584 KB

## Abstract Prolongation of the QT interval of the electrocardiogram is a typical effect of Class III antiarrhythmic drugs, achieved through blockade of potassium channels. In the past decade, evidence has accrued that several classes of drugs used for non‐cardiovascular indications may prolong the