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Opioids and efflux transporters. Part 1: P-Glycoprotein substrate activity of N-substituted analogs of meperidine

✍ Scribed by Susan L. Mercer; Hazem E. Hassan; Christopher W. Cunningham; Natalie D. Eddington; Andrew Coop


Book ID
108074247
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
137 KB
Volume
17
Category
Article
ISSN
0960-894X

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The human multidrug resistance gene MDR1 encodes the protein product P-glycoprotein (P-gp). P-gp is an integral membrane protein which mediates ATP-dependent substrate efflux. We recently discovered a novel G --> T variant at 1199 nucleotide position of MDR1 which exhibits a 2.3% allelic frequency i