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Opioid tolerance in neonates: Mechanisms, diagnosis, assessment, and management

✍ Scribed by Santhanam Suresh; K.J.S. Anand


Book ID
114121104
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
961 KB
Volume
22
Category
Article
ISSN
0146-0005

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The molecular basis of opioid tolerance/dependence has long eluded researchers, but recent advances in receptor regulation have suggested a useful conceptual approach to the problem. In NG108-15 neuroblastoma x glioma hybrid (NG) cells, opioid agonists inhibit adenylate cyclase in a dose-dependent,