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Opioid receptor upregulation in μ-opioid receptor deficient CXBK and outbred Swiss Webster mice

✍ Scribed by Alokesh Duttaroy; Ji Shen; Sukrut Shah; Billy Chen; Fatima Sehba; Joanne Carroll; Byron C. Yoburn

Book ID
117176294
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
901 KB
Volume
65
Category
Article
ISSN
0024-3205

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In vivo regulation of μ-opioid receptor
In vivo regulation of μ-opioid receptor density and gene expression in CXBK and outbred Swiss Webster mice
✍ Alokesh Duttaroy; Byron C. Yoburn 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 92 KB

Chronic in vivo treatment with the opioid agonist etorphine downregulates mu-opioid receptor density, produces tolerance, and regulates gene expression in the mouse. After cessation of treatment, there is an increase in mu-opioid receptor mRNA level associated with the recovery of mu-opioid receptor