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Opioid receptor activation prevents reperfusion injury by targeting mitochondrial permeability transition

✍ Scribed by Youngho Jang; Huihua Wang; Jinkun Xi; Robert A. Mueller; Edward Norfleet; Zhelong Xu


Book ID
116985071
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
50 KB
Volume
42
Category
Article
ISSN
0022-2828

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We investigated the effects of nitric oxide (NO) on hepatocellular killing after simulated ischemia/reperfusion and characterized signaling factors triggering cytoprotection by NO. Cultured rat hepatocytes were incubated in anoxic Krebs-Ringer-HEPES buffer at pH 6.2 for 4 hours and reoxygenated at p