Opioid Peptides and Blood Pressure Control

✍ Scribed by A. I. Faden, K. Kraft, K. O. Stumpe (auth.), Prof. Dr. med. K. O. Stumpe, Dr. med. Karin Kraft, Prof. med. A. I. Faden (eds.)

• Publisher: Springer-Verlag Berlin Heidelberg
• Year: 1988
• Tongue: English
• Leaves: 302
• Edition: 1
• Category: Library

✦ Synopsis

This book provides current knowledge on the influence of endogenous opioid peptides on blood pressure regulation. In view of the rapid increase in knowledge in the field, it is important that scientists in blood pressure research as well as specialist clinicians have access to such a comprehensive survey. The book is divided into sections on neuroanatomy, where both the central and peripheral nervous systems are considered; on physiology and pharmacology, whereby experiments with intact animals as well as with histologic preparations are described; and on clinical questions, where examinations of normotensive and hypertensive patients as well as experiments on the influence of various drugs are emphasized. The contributions are presented in the form of reviews and single articles which allow the reader to obtain a clear and detailed survey of a range of highly topical subjects.

✦ Table of Contents

Front Matter....Pages I-VIII
Endogenous Opioids and Cardiovascular Regulation: Introduction....Pages 1-2
Front Matter....Pages 3-3
Distribution of Opioid Peptides Functionally Related to the Cardiovascular System....Pages 5-12
Studies on Enkephalinergic Mechanisms in Cardiovascular Centers of the Medulla Oblongata of the Rat and their Interactions with Centrally Administered Neuropeptide Y....Pages 13-26
Multiplicity of Opioidergic Pathways Related to Cardiovascular Innervation: Differential Contribution of All Three Opioid Precursors....Pages 27-49
Front Matter....Pages 51-51
Opioids, Opiate Receptors, and Central Cardiovascular Regulation....Pages 53-61
Adrenergic-Opioid Interaction in the Brains System: Role in Cardiovascular Regulation....Pages 62-70
Influence of the Opioid System on Sympathetic Activity and the Renin-Aldosterone System in Healthy Males....Pages 71-82
Role of Leu-morphin, an Opioid Peptide, in the Central Regulation of Fluid Balance and Blood Pressure in Rats....Pages 83-89
Endogenous Opioids in the Dorsal Vagal Complex and Resting Cardiovascular Function in the Anesthetized Rat....Pages 90-97
Influence of Opiate Peptides on Blood Pressure Regulation and on Hypothalamic Blood Flow....Pages 98-102
Opioid Peptides in Human Adrenal Medulla: Their Role in the Modulation of Catecholamine Secretion....Pages 103-111
Cardiovascular effects of Neuropeptide Y in the Caudal Ventrolateral Medulla....Pages 112-116
Plasma Met-enkephalin and Cardiovascular Responses to Stress....Pages 117-126
Front Matter....Pages 127-127
Opioid Receptors in the Sympathetic Supply to Blood Vessels and the Heart....Pages 129-140
Interactions of Opioid Peptides and Adrenergic Agents in the Regulation of Blood Pressure....Pages 141-149
Effect of Opiate Receptor Blockade on the Cardiovascular and Plasma Noradrenaline Response to Intravenous Tyramine in Man....Pages 150-158
Effects of Mu- and Delta-Opiate Receptor Agonists on Systemic and Regional Hemodynamics in Conscious Rats....Pages 159-167
Retardment of Development of Hypertension in the Spontaneously Hypertensive Rat by Long-Term Kappa-Opioid Receptor Antagonism....Pages 168-173
Naltrexone Inhibits Alpha-Methyldopa-Induced Hypotension in a Dose-Dependent Manner....Pages 174-182
Effects of 17-alpha-Estradiol, a Possible Endogenous Opiate Antagonist, on Cardiovascular Responses in Conscious, Unrestrained Rats....Pages 183-189
Front Matter....Pages 127-127
Opioid Receptor Types at Noradrenergic Neurons and their Roles in Blood Pressure Regulation....Pages 190-205
Effects of Opioids on Plasma Levels of Immunoreactive Atrial Natriuretic Factor....Pages 206-211
Production by Systemic Enkephalin of Hemodynamic Effects by Afferent Modulation of Autonomic Nervous System Tone....Pages 212-218
Front Matter....Pages 219-219
Endogeneous Opioids in the Pathophysiology of Shock: Sites of Action, Autonomic Involvement, and Receptor Interactions....Pages 221-232
Endogenous Opioids and Blood Pressure in Man....Pages 233-235
Effects of Hemorrhagic Shock on Plasma Met-enkephalin, Vasopressin, Catecholamines, and Cardiovascular Functions in Intact and Adrenalectomized Dogs....Pages 236-246
Effect of Hypertension on the Response of Plasma Beta-Endorphin to the Cold Pressor Test....Pages 247-252
Normalization by Clonidine of Reduced Plasma Beta-endorphin and Leu-enkephalin Concentrations and Elevated Blood Pressure in Young Patients with Mild Essential Hypertension....Pages 253-259
Role of Opioids in the Pathophysiology of Hypertension....Pages 260-274
Effect of Low Dosage of Naloxone on Clonidine- Induced Changes in Blood Pressure, Catecholamines, Renin, and Aldosterone in Essential Hypertension....Pages 275-281
Effect of Lisinopril on Circulating Neuropeptides in Essential Hypertensive Patients....Pages 282-286
Endogenous Opioids and Reversal of Renovascular Hypertension....Pages 287-293
Comparison of Pain Threshold as Assessed by Tooth Pulp Stimulation in Normotensives with Different Hypertensive Hereditary Backgrounds and in Borderline and Established Hypertensives....Pages 294-298
Back Matter....Pages 299-300

✦ Subjects

Human Physiology; Cardiology; Neurosciences; Pharmacology/Toxicology