Opioid antagonists and the sexual satiation phenomenon
✍ Scribed by G. Rodríguez-Manzo; A. Fernández-Guasti
- Publisher
- Springer
- Year
- 1995
- Tongue
- English
- Weight
- 960 KB
- Volume
- 122
- Category
- Article
- ISSN
- 0033-3158
No coin nor oath required. For personal study only.
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The solid state structures of two synthetic opioid peptides have been determined by X-ray single crystal analysis. The first X-ray structure is that of N,N-diallyl-(O-t-butyl)-Tyr-Aib-Aib-Phe-Leu-OMe (RTI02), a protected derivative of the 5-receptor selective antagonist ICI 174,864 (N,N-diallyl-Tyr-
The discovery of the prototype ␦ opioid antagonists TIPP (H-Tyr-Tic-Phe-Phe-OH) and TIP (H-Tyr-Tic-Phe-OH) in 1992 was followed by extensive structure-activity relationship studies, leading to the development of analogues that are of interest as pharmacological tools or as potential therapeutic agen