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Opiate antagonists: central sites of action in suppressing water intake of the rat

โœ Scribed by David R. Brown; Stephen G. Holtzman


Book ID
118866932
Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
256 KB
Volume
221
Category
Article
ISSN
0006-8993

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The effects of naltrexone methobromide, a quaternary derivative of the opioid antagonist naltrexone, were investigated on deprivation (24 h)-induced water intake in the unilaterally cannulated rats. Naltrexone methobromide reduced post-deprivational water intake with an ED50 of 7.3 micrograms when t