Open tubular column supercritical fluid chromatography/mass spectrometry on a benchtop mass spectrometer

✍ Scribed by Lee, E. D. ;Henion, J. D.

• Publisher: John Wiley and Sons
• Year: 1986
• Tongue: English
• Weight: 273 KB
• Volume: 9
• Category: Article
• ISSN: 0935-6304
• DOI: 10.1002/jhrc.1240090308

✦ Synopsis

A benchtop SFCIMS system is described which utilizes supercritical carbon dioxide in a 50 micron diameter open tubular column interfaced directly to an unchanged commercially available benchtop capillary GCIMS system equipped with a chemical ionization (Cl) source. A small amount of methane reagent gas was admitted co-axially to a capillary restrictor at the exit of the capillary chromatographic column. This make-up gas served as the CI reagent gas and appeared to optimize the sensitivityof thesystem while providing abundant (M+l) ionsfor the analytes investigated in this study. Good chromatographic integrity was obtained for the GCIMS test compound, decafluorotriphenylphosphine (DFTPP), but the capillary restrictor appeared to cause some tailing of the ion current profiles resulting from low nanogram levels of caffeine and some fatty acid esters. Improvements in the SFCIMS capillary restrictor interface and the pumping system of the benchtop GCIMS system should increase the capability of this system for future applications.