Open probability of the epithelial sodium channel is regulated by intracellular sodium
โ Scribed by Arun Anantharam; Yuan Tian; Lawrence G. Palmer
- Book ID
- 110113956
- Publisher
- Cambridge University Press
- Year
- 2006
- Tongue
- English
- Weight
- 656 KB
- Volume
- 574
- Category
- Article
- ISSN
- 0022-3751
No coin nor oath required. For personal study only.
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The first step in net active transepithelial transport of sodium in tight epithelia is mediated by the amiloride-blockable sodium channel in the apical membrane. This sodium channel is the primary site for discretionary control of total body sodium and, therefore, investigating its regulatory mechan
The properties of the Na-K pump and some of the factors controlling its amount and function were studied in rat myotubes in culture. The number of Na-K pump sites was quantified by measuring the amount of [3H]ouabain bound to whole-cell preparations. Activity of the pump was determined by measuremen