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Open channel block of Kv1.3 by rosiglitazone and troglitazone: Kv1.3 as the pharmacological target for rosiglitazone

✍ Scribed by Hye Sook Ahn; Sung Eun Kim; Hyun-Jong Jang; Myung-Jun Kim; Duck-Joo Rhie; Shin-Hee Yoon; Yang-Hyeok Jo; Myung-Suk Kim; Ki-Wug Sung; Seong Yun Kim; Sang June Hahn


Publisher
Springer-Verlag
Year
2006
Tongue
English
Weight
164 KB
Volume
374
Category
Article
ISSN
0028-1298

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## Abstract The voltage‐gated Kv1.3 and the calcium‐activated KCa3.1 potassium channel modulate many calcium‐dependent cellular processes in immune cells, including T‐cell activation and proliferation and have therefore been proposed as novel therapeutic targets for immunomodulation. Kv1.3 is highl