𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Open-access high-resolution mass spectrometry in early drug discovery

✍ Scribed by Steven R. Thomas; Ute Gerhard

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
276 KB
Volume
39
Category
Article
ISSN
1076-5174

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Techniques such as mass spectrometry and NMR spectroscopy form an essential part of the medicinal chemist's toolbox for characterizing and assessing the purity of new molecules. Empowering medicinal chemists to gain early insight into their reaction products has a direct impact on productivity. Devolution of cutting‐edge techniques from the specialist to the bench chemist also frees the specialist to concentrate on solving the more demanding of analytical problems. For open‐access techniques to be taken up, they must be robust and be able to handle differing sample concentrations and varying sample complexities. This paper details the implementation of high‐resolution liquid chromatography/mass spectrometry in open access to aid the medicinal chemist in characterizing desired products and identifying unexpected rearrangements, by‐products and complete unknowns. Copyright © 2004 John Wiley & Sons, Ltd.

📜 SIMILAR VOLUMES

Open-access liquid chromatography/mass s
Open-access liquid chromatography/mass spectrometry in a drug discovery environment
✍ Larry M. Mallis; Ani B. Sarkahian; John M. Kulishoff Jr; William L. Watts Jr 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 260 KB

## Abstract The use of open‐access mass spectrometry to monitor synthetic chemistry reactions, and also the integrity and purity of new chemical entities, has been a part of the medicinal chemist's tool‐box for more than 5 years. Originally in our group at Wyeth Research there were two open‐access

Demonstration of the capabilities of a p
Demonstration of the capabilities of a parallel high performance liquid chromatography tandem mass spectrometry system for use in the analysis of drug discovery plasma samples
✍ Walter A. Korfmacher; John Veals; Kimberly Dunn-Meynell; Xiping Zhang; Greg Tuck 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 102 KB 👁 3 views

There is a continuing need for increased throughput in the evaluation of new drug entities in terms of their pharmacokinetic (PK) parameters. This report describes an alternative procedure for increasing the throughput of plasma samples assayed in one overnight analysis: the use of parallel high per

Isolation of circulating metabolites in
Isolation of circulating metabolites in drug discovery using high-performance liquid chromatography, and their identification by liquid chromatography coupled with tandem mass spectrometry and nuclear magnetic resonance spectroscopy
✍ Hong Kim; Wenqing Feng; Tze-Ming Chan; Diane Rindgen; Matthew Bryant; Kathleen A 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 221 KB 👁 3 views

Isolation of circulating metabolites in drug discovery using high-performance liquid chromatography, and their identification by liquid chromatography coupled with tandem mass spectrometry and nuclear magnetic resonance spectroscopy One of the major components of modern drug discovery is the structu