OP23.01: A prospective study evaluating the performance of first trimester combined screening for trisomy 21 using repeated sampling of the maternal serum markers PAPP-A and free β-hCG
✍ Scribed by C. K. Ekelund; D. Wright; S. Ball; I. Kirkegaard; P. Noergaard; F. S. Joergensen; S. Soerensen; L. Friis-Hansen; N. Toerring; B. H. Bech; O. B. Petersen; A. Tabor
- Book ID
- 115562993
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 60 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0960-7692
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In the ®rst trimester of pregnancy the biochemical markers free b-hCG and pregnancy associated plasma protein-A (PAPP-A) are used for the prenatal screening of trisomy 21, either alone or in combination with nuchal translucency (NT) thickness. In this study, I have analysed the distribution of these
In a study of 2923 normal pregnancies and 203 pregnancies affected by trisomy 21 we have shown a signi®cant difference in the median MoM of the markers: fetal nuchal translucency, maternal serum free b-hCG and PAPP-A in the presence of a female fetus compared with a male fetus. For maternal serum fr
In a population of 1467 women attending the 'G. Gaslini' Institute for antenatal care, we evaluated first-trimester risk screening for Down syndrome using the 'combined test' based on ultrasound measurement of nuchal translucency (NT), maternal serum pregnancy-associated plasma protein A (PAPP-A) an