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OP0253 The JAK Inhibitor Tofacitinib Suppresses Synovial JAK1-STAT1 Signalling in Rheumatoid Arthritis

✍ Scribed by Boyle, D. L.; Wei, N.; Singhal, A. K.; Rosengren, S.; Kaplan, I.; Soma, K.; Hodge, J.; Luo, Z.; Krishnaswami, S.; Gruben, D.; Zwillich, S. H.; Bradley, J.; Firestein, G. S.


Book ID
123606917
Publisher
BMJ Publishing Group
Year
2013
Tongue
English
Weight
363 KB
Volume
72
Category
Article
ISSN
0003-4967

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## Abstract Aberrant janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling is involved in the oncogenesis of several cancers. Suppressors of cytokine signaling (SOCS) genes and SH2‐containing protein tyrosine phosphatase 1 (SHP1) proteins, which are negative regulator