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Onycholysis and subungual haemorrhages secondary to systemic chemotherapy (paclitaxel)

✍ Scribed by E Ghetti; BM Piraccini; A Tosti

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 58 KB
Volume: 17
Category: Article
ISSN: 0926-9959
DOI: 10.1046/j.1468-3083.2003.00774.x

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✦ Synopsis

ABSTRACT

Paclitaxel is a chemotherapic agent of the taxane family used in treatment of malignant solid tumory. We report here the case of a 40‐year old woman referred to our clinic for nail changes involving all 20 digits and developed after 5 months of paclitaxel intake, due to a breast carcinoma.

Clinical examination revealed red‐brown discoloration of the nails associated with hematomas and onycholysis. The nail changes were very painful and the patient complained of discharge of bad‐smelling yellow brown opaque fluid from underneath the nail plate.

Hemorrhagic onycholysis and subungual abscesses are a possible side effect of taxane treatment that should be early recognized to prevent serious complications.

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✍ Sabir Hussain; Dina N. Anderson; Mary Ellen Salvatti; Barbara Adamson; Margaret 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 262 KB 👁 2 views

## Background: Onycholysis has been reported in association with the use of several noncytotoxic drugs and with chemotherapy in 135 patients. onycholysis may be precipitated by exposure to ultraviolet radiation. ## Methods: The authors studied 91 patients who received paclitaxel and 187 patients