Ontologies for proteomics: towards a systematic definition of structure and function that scales to the genome level
✍ Scribed by Ning Lan; Gaetano T Montelione; Mark Gerstein
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 202 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1367-5931
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✦ Synopsis
A principal aim of post-genomic biology is elucidating the structures, functions and biochemical properties of all gene products in a genome. However, to adequately comprehend such a large amount of information we need new descriptions of proteins that scale to the genomic level. In short, we need a unified ontology for proteomics. Much progress has been made towards this end, including a variety of approaches to systematic structural and functional classification and initial work towards developing standardized, unified descriptions for protein properties. In relation to function, there is a particularly great diversity of approaches, involving placing a protein in structured hierarchies or more-generalized networks and a recent approach based on circumscribing a protein's function through systematic enumeration of molecular interactions.