Characterization of an inducible, epider
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Thomas R. Berton; Xiao-Jing Wang; Zhijian Zhou; Christoph Kellendonk; Günther Sc
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Article
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2000
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John Wiley and Sons
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English
⚖ 265 KB
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To generate epidermal-specific knockout mice, vectors can be used to target expression of Cre recombinase to epidermal stem cells. Cre-mediated recombination is then used to delete gene sequences flanked by loxP sites ("floxed gene"). However, most keratin-based expression vectors (e.g., K14, which