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Ontogenic aspects of liver and kidney catechol-O- methyltransferase sensitivity to tolcapone

โœ Scribed by M.A. Vieira-Coelho; P. Soares-da-Silva


Book ID
115289795
Publisher
Nature Publishing Group
Year
1996
Tongue
English
Weight
909 KB
Volume
117
Category
Article
ISSN
0007-1188

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Object&z-To assess the tolerability, pharmacokinetics and pharmacodynamics of single oral doses of the novel catechol-0-methyltransferase (COMT) inhibitor tolcapone in healthy volunteers. Metbuuk In this double-blind, placebo-controlled, ascending-single-dose study, doses of 5 to 800 mg tolcapone w