Ontogenetic development of proenkephalin A and proenkephalin B messenger RNA in fetal pigs

✍ Scribed by C. W. Pittius; F. Ellendorff; V. Höllt; N. Parvizi

• Book ID: 104680568
• Publisher: Springer-Verlag
• Year: 1987
• Tongue: English
• Weight: 640 KB
• Volume: 69
• Category: Article
• ISSN: 0014-4819
• DOI: 10.1007/bf00247043

✦ Synopsis

Using solution hybridization analysis and Northern blotting with complementary RNA probes labelled to high specific activity, levels of proenkephalin A and B mRNA were analyzed throughout prenatal development in the hippocampus and striatum of fetal pigs. A differential time course for the appearance of these opioid precursor mRNAs was observed: in hippocampus, both mRNAs increased linearly throughout development with proenkephalin B mRNA increasing faster than proenkephalin A mRNA. In striatum, both mRNAs behaved similarly, increasing to a maximum level around mid-gestation and declining thereafter. The differences might be attributed to differential localization of the two precursor systems in the tissues and might be of functional relevance.